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Week One
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Tuesday: (01.07.03)
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1. Falconer DS (1965). The inheritance of liability to certain
diseases, estimated from the incidence among relatives. Ann. Hum. Genet. (London)
29:51-76. [PDF]
2. Risch, N (1990). Linkage Strategies for
Genetically complex traits II. The power of affected relative pairs. AJHG
46: 229-241. [PDF]
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Thursday: (01.09.03)
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1. Pritchard, JK (2001) Are rare variants responsible
for susceptibility to complex diseases? AJHG 69:124-137. [PDF]
2. Reich DE and Lander ES (2001) On the allelic spectrum of human disease.
Trends Genet. 17(9):502-510. [PDF]
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Optional Week One Reading:
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1. Risch N (1990). Linkage
Strategies for genetically complex traits I. Multilocus models. AJHG
46:222-228. [PDF]
2. Lalouel J-M et al. (1983) A unified model for
complex segregation analysis. AJHG 35:816-826. [PDF]
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Week Two
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Tuesday: (01.14.03)
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1. Suarez BK and Cox NJ
(1982). Linkage Analysis
I. Basic Concepts. [PDF]
2. Kruglyak L et al. (1996). Parametric and nonparametric
linkage analysis: A unified multipoint approach. AJHG 58:1347-1363. [PDF]
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Thursday: (01.16.03)
1. Davies et al. (1994). A genome-wide search for human type I diabetes
susceptibility genes. Nature 371:130-136. [PDF]
2. Cox NJ et al (2001). Seven regions of the genome show evidence of
linkage to type 1 diabetes in a consensus analysis
of 767 multiplex families. AJHG 69:820-830. [PDF]
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Week Three
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Tuesday: (01.21.03)
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1. Jorde LB (2000). Linkage disequilibrium
and the search for complex disease genes. Genome Res
10:1435-1444. [PDF]
2. Weiss KM and Clark AG (2002) Linkage disequilibrium and the mapping of complex
human traits. Trends Genetics 18:19-24. [PDF]
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Thursday: (01.23.03)
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1. Spielman RS et al (1993). Transmission
test for linkage disequilibrium: The insulin gene region and insulin
dependent diabetes mellitus (IDDM). AJHG 52:506-516. [PDF]
2. Spielman RS and Ewens
WJ (1996) The TDT and other family-based tests for linkage disequilibrium
and association. AJHG 59:983-989. [PDF]
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Week Four
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1. Pritchard et al (2000). Association Mapping in
Structured Populations. AJHG 67:170-181. [PDF]
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2. Gabriel et al (2002). The Structure of Haplotype Blocks in the Human Genome. Science
296:2225-2229. [PDF]
[Supp.
Mat'l]
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3. Slatkin M. and Excoffier L. (1995). Maximum-Likelihood Estimation of
Molecular Haplotype Frequencies in a Diploid
Population. Mol. Biol. Evol. 12:921-927. [PDF]
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Week Five
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1. McPeek and Strahs (1999). Assessment of Linkage Disequilibrium by
the Decay of Haplotype Sharing, with Application
to Fine Scale Genetic Mapping. AJHG 65:858-875. [PDF]
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2. Risch and Merikangas (1996). The Future of Genetic Studies of
Complex Human Diseases. Science 273:1516-1517 [PDF]
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3. Risch (2000). Searching for
genetic determinants in the new millenium. Nature
405:847-856. [PDF]
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Week Six
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Thursday: (02.13.03)
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1. Selected Readings:
Walsh and Lynch (1998). Genetics and Analysis of Quantitative Traits.
182-189, 745-751. [PDF]
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Week Seven
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Tuesday: (02.18.03)
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1. McPeek and Sun (2000). Statistical
Tests for Detection of Misspecfied Relationships
by Use of Genome-Screen Data. AJHG 66:1076-1094. [PDF]
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2. Sobel et al. (2002). Detection
and Integration of Genotyping Errors is Statistical Genetics. AJHG
70:496-508. [PDF]
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Week Eight
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Tuesday: (02.25.03)
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1. Boehnke, M. (2002). A look
at Linkage Disequilibrium. Nat. Genet. 25:246-247. [PDF]
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Thursday: (02.27.03)
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1. Wiltshire et al. (2002). Evaluating the Results of Genomewide Linkage Scans of Complex Traits by Locus
Counting. AJHG 71: 1175-1182. [PDF]
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2. Lander, ES and Kruglyak, L.
(1995). Genetic Dissection of Complex Traits: Guidelines for Interpreting
and Reporting Linkage Results. Nat. Genet. 11(3):241-247. [PDF]
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Friday: (02.28.03)
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1. Rabiner, L. (1989). A
Tutorial on Hideen Markov Models and Selected
Applications in Speech Recognition. Proc. IEEE. 77:257-274, 284-285. [PDF]
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Week Nine
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1. Cox et al. (1999) Loci on chromosomes 2 (NIDDM1) and
15 interact to increase susceptibility to diabetes in Mexican Americans.
Nat. Genet. 21:213-215. [PDF]
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2. Sun L, Cox, NJ, and McPeek,
S. (2002). A Statistical Method for Identification of Polymorphisms that
Explain a Linkage Result. AJHG 70:399-411. [PDF]
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3. Hoh J. et al (2001).
Trimming, weighting, and grouping SNPs in human
case-control association studies. Genome Res. 11:2115-2119. [PDF]
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Week Ten
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Tuesday: (03.11.03)
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1. Hoh et al (from above)
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2. Horikawa, Y. et al. (2000).
Genetic variation in the gene encoding calpain-10 is associated with type 2
diabetes mellitus. Nat. Genet. 26: 163-175. [PDF]
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Thursday: (03.13.03)
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1. Stefansson, H. et al.
(2002). Neuregulin 1 and susceptibility to
schizophrenia. AJHG 71: 877-892. [PDF]
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2. Van Eerdewegh, P. et al (2002).
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418: 426-430. [PDF]
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