Publications

1.	Hanna GL, Veenstra-VanderWeele J, Cox NJ, Boehnke M, Himle JA, Curtis GC, Leventhal BL, Cook EH Jr.

Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. 
Am J Med Genet. 2002 Jul 8;114(5):541-52.

 

2.	Haddad L, Evans JC, Gharani N, Robertson C, Rush K, Wiltshire S, Frayling TM, Wilkin TJ, Demaine A, Millward A, Hattersley AT, Conway G, Cox NJ, Bell GI, Franks S, McCarthy MI.

Variation within the type 2 diabetes susceptibility gene calpain-10 and polycystic ovary syndrome. 
J Clin Endocrinol Metab. 2002 Jun;87(6):2606-10.

 

3.	Ehrmann DA, Schwarz PE, Hara M, Tang X, Horikawa Y, Imperial J, Bell GI, Cox NJ.

Relationship of calpain-10 genotype to phenotypic features of polycystic ovary syndrome.
J Clin Endocrinol Metab. 2002 Apr;87(4):1669-73.

4.	Fullerton SM, Bartoszewicz A, Ybazeta G, Horikawa Y, Bell GI, Kidd KK, Cox NJ, Hudson RR, Di Rienzo A.

Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus.
Am J Hum Genet. 2002 May;70(5):1096-106.

 

5.

Cox NJ.

Computational issues in mapping variation affecting susceptibility to complex disorders: the chicken and the egg.
Theor Popul Biol. 2001 Nov;60(3):221-5.

 

6.	Hara M, Alcoser SY, Qaadir A, Beiswenger KK, Cox NJ, Ehrmann DA.

Insulin resistance is attenuated in women with polycystic ovary syndrome with the Pro(12)Ala polymorphism in the PPARgamma gene.
J Clin Endocrinol Metab. 2002 Feb;87(2):772-5.

 

7.	Elbein SC, Chu W, Ren Q, Hemphill C, Schay J, Cox NJ, Hanis CL, Hasstedt SJ.

Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians.
J Clin Endocrinol Metab. 2002 Feb;87(2):650-4.

 

8.	Sun L, Cox NJ, McPeek MS.

A statistical method for identification of polymorphisms that explain a linkage result.
Am J Hum Genet. 2002 Feb;70(2):399-411.

 

9.	Lynn S, Evans JC, White C, Frayling TM, Hattersley AT, Turnbull DM, Horikawa Y, Cox NJ, Bell GI, Walker M.

Variation in the calpain-10 gene affects blood glucose levels in the British population.
Diabetes. 2002 Jan;51(1):247-50.

 

10.	Nicolae DL, Cox NJ.

MERLIN...and the geneticist's stone?
Nat Genet. 2002 Jan;30(1):3-4.

 

11.

Cox NJ.

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene.
Hum Mol Genet. 2001 Oct 1;10(20):2301-5. Review.

 

12.	Newman DL, Abney M, McPeek MS, Ober C, Cox NJ.

The importance of genealogy in determining genetic associations with complex traits.
Am J Hum Genet. 2001 Nov;69(5):1146-8. No abstract available.

 

13.	Sreenan SK, Zhou YP, Otani K, Hansen PA, Currie KP, Pan CY, Lee JP, Ostrega DM, Pugh W, Horikawa Y, Cox NJ, Hanis CL, Burant CF, Fox AP, Bell GI, Polonsky KS.

Calpains play a role in insulin secretion and action.
Diabetes. 2001 Sep;50(9):2013-20.

 

14.	Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P.

Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
Am J Hum Genet. 2001 Oct;69(4):820-30.

 

15.	Evans JC, Frayling TM, Cassell PG, Saker PJ, Hitman GA, Walker M, Levy JC, O'Rahilly S, Rao PV, Bennett AJ, Jones EC, Menzel S, Prestwich P, Simecek N, Wishart M, Dhillon R, Fletcher C, Millward A, Demaine A, Wilkin T, Horikawa Y, Cox NJ, Bell GI, Ellard S, McCarthy MI, Hattersley AT.

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom.
Am J Hum Genet. 2001 Sep;69(3):544-52.

 

16.	Xu J, Meyers DA, Ober C, Blumenthal MN, Mellen B, Barnes KC, King RA, Lester LA, Howard TD, Solway J, Langefeld CD, Beaty TH, Rich SS, Bleecker ER, Cox NJ.

Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma.
Am J Hum Genet. 2001 Jun;68(6):1437-46.

 

17.	Colilla S, Cox NJ, Ehrmann DA.

Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives.
J Clin Endocrinol Metab. 2001 May;86(5):2027-31.

 

18.	Mathias RA, Freidhoff LR, Blumenthal MN, Meyers DA, Lester L, King R, Xu JF, Solway J, Barnes KC, Pierce J, Stine OC, Togias A, Oetting W, Marshik PL, Hetmanski JB, Huang SK, Ehrlich E, Dunston GM, Malveaux F, Banks-Schlegel S, Cox NJ, Bleecker E, Ober C, Beaty TH, Rich SS.

Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Genet Epidemiol. 2001 Apr;20(3):340-55.

 

19.	del Bosque-Plata L, Lin J, Horikawa Y, Schwarz PE, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, German MS, Bell GI.

Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset diabetes of the young in Japanese subjects.
Diabetes. 2001 Mar;50(3):694-6.

 

20.	Horikawa Y, Horikawa Y, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, Schwitzgebel V, German MS, Bell GI.

beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurogenic differentiation 4 (NEUROD4) in Japanese patients with MODY.
Diabetes. 2000 Nov;49(11):1955-7.

 

21.	Ober C, Tsalenko A, Parry R, Cox NJ.

A second-generation genomewide screen for asthma-susceptibility alleles in a founder population.
Am J Hum Genet. 2000 Nov;67(5):1154-62.

 

22.	Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C.

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.
J Clin Invest. 2000 Oct;106(7):R69-73.

 

23.	Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI.

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
Nat Genet. 2000 Oct;26(2):163-75.

 

24.	Hara M, Wang X, Paz VP, Cox NJ, Iwasaki N, Ogata M, Iwamoto Y, Bell GI.

No diabetes-associated mutations in the coding region of the hepatocyte nuclear factor-4gamma gene (HNF4G) in Japanese patients with MODY.
Diabetologia. 2000 Aug;43(8):1064-9.

 

25.	Hinokio Y, Horikawa Y, Furuta H, Cox NJ, Iwasaki N, Honda M, Ogata M, Iwamoto Y, Bell GI.

Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young.
Diabetes. 2000 Feb;49(2):302-5.

 

26.	Ober C, Leavitt SA, Tsalenko A, Howard TD, Hoki DM, Daniel R, Newman DL, Wu X, Parry R, Lester LA, Solway J, Blumenthal M, King RA, Xu J, Meyers DA, Bleecker ER, Cox NJ.

Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
Am J Hum Genet. 2000 Feb;66(2):517-26.

 

27.	Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, Bell GI, Kong A.

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.
Nat Genet. 1999 Feb;21(2):213-5.

 

28.	Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance M, Pettersson A, Prescott J, Richardson A, Schlenker E, Summerhill E, Willadsen S, Parry R.

Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma.
Hum Mol Genet. 1998 Sep;7(9):1393-8.

 

29.	Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, Stirling B, Mitra M, Farmer J, Williams SR, Cox NJ, Bell GI, Risch N, Spielman RS.

A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus.
Nat Genet. 1998 Jul;19(3):292-6.

 

30.	Ober C, Cox NJ.

The genetics of asthma. Mapping genes for complex traits in founder populations.
Clin Exp Allergy. 1998 Apr;28 Suppl 1:101-5;

 

31.	Cook EH Jr, Courchesne RY, Cox NJ, Lord C, Gonen D, Guter SJ, Lincoln A, Nix K, Haas R, Leventhal BL, Courchesne E.

Linkage-disequilibrium mapping of autistic disorder, with 15q11-13 markers.
Am J Hum Genet. 1998 May;62(5):1077-83.

 

32.	Kong A, Cox NJ.

Allele-sharing models: LOD scores and accurate linkage tests.
Am J Hum Genet. 1997 Nov;61(5):1179-88.

33.	Boehnke M, Cox NJ.

Accurate inference of relationships in sib-pair linkage studies.
Am J Hum Genet. 1997 Aug;61(2):423-9.

 

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